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For type 2 diabetes, NICE recommends GLP-1 agonists when other treatments haven't achieved target HbA1c levels, with specific consideration for cardiovascular and renal risk factors according to NICE guideline NG28
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Research shows that semaglutide can reduce heart attack and stroke risk, as well as treat renal insufficiency and delay progression to renal failure in people with type 2 diabetes, providing broader health benefits beyond glucose control.
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