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Probiotics (live beneficial microorganisms), prebiotics (selectively fermentable substrates), and postbiotics (microbial-derived metabolites or functional components) represent complementary approaches aimed at improving gut microbial composition and function, thereby potentially reinforcing incretin signaling and metabolic outcomes (108)

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These findings suggest that the addition of GLP-1 receptor agonists to metformin therapy may mitigate certain serious adverse effects associated with metformin monotherapy