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Strategies to increase half-life To design GLP-RAs with an increased circulation time, a broad array of half-life extension strategies has been utilized including sequential modification (Byetta® and Adlyxin®), attachment of a fatty-acid (Victoza® and Ozempic®), development of a polymer-based sustained release formulation (Bydureon®), fusion with human serum albumin (Tanzeum®), and fusion with the fragment crystallizable (Fc) region of a monoclonal antibody (Trulicity®) (Figure 1)
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The retatrutide 20mg dosing guide covers extended protocols, but the foundational data starts here
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