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The authors reported that conversion of the N-terminal His to Phe resulted in an Ex-4 analog with improved efficacy at inducing insulin release while eliciting reduced levels of receptor internalization and β-arrestin-2 recruitment 49
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We also observed increased tissue weights for heart and kidneys in female but not male SKO mice, consistent with previously reported organomegaly in this model ( Supplementary Figures S1C, D ) Finally, blood glucose levels were examined in the non-fasted state before and after 10 days of treatment
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