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Some laboratory studies suggest that GLP-1 analogues may modulate these neurotransmitter systems, potentially affecting cognitive performance and impulsivity, though these findings remain largely preclinical
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A study comparing the two last year found "patients receiving oral semaglutide had a significantly higher risk of treatment discontinuation due to side effects." In a clinical trial of the injectable Zepbound and Wegovy, 6% to 8% left the trial because of adverse side effects
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