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Comparison of insulin glargine and liraglutide added to oral agents in patients with poorly controlled type 2 diabetes

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Moreover, dual-agonist bicistronic mRNA platforms—for instance, those encoding GLP-1 and FGF21—demonstrate broader therapeutic coverage in obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) models, where they simultaneously address energy metabolism, insulin sensitivity, and hepatic lipid clearance [439, 440]

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