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However, other studies in rats show that injection of Ex-4 into the medial subnucleus of the NTS produced CTA whereas injection into the CeA did not induce CTA (Kanoski et al., 2012)
Metabolism
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NICE approved semaglutide (Wegovy) for weight management in specialist NHS weight management services in 2023 (TA875), but availability is limited to patients with: BMI ≥35 kg/m² with at least one weight-related comorbidity, or BMI ≥30 kg/m² with exceptional circumstances Lower BMI thresholds apply for people from some minority ethnic groups (typically ≥27.5 kg/m²) Participation in a specialist weight management programme Treatment limited to a maximum of 2 years Access varies by region due to local integrated care board (ICB) implementation decisions and limited NHS specialist service capacity
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