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Tier 3: 10-15% Weight Loss (Early Data / Oral Agents)# This tier consists primarily of oral formulations with shorter trial durations or lower doses: VK2735 SC (14.7% at 13 wk) -- Impressive trajectory for a 13-week trial Oral semaglutide 25 mg (13.6% at 64 wk) -- Approved dose, competitive with injectable Oral amycretin (13.1% at 12 wk) -- Extraordinary 12-week result for an oral drug Oral VK2735 (12.2% at 13 wk) -- Strong oral dual agonist result Oral ribupatide (~12% at 26 wk) -- Dual agonist oral formulation Orforglipron (11.2% at 72 wk) -- The most mature Phase 3 oral data Rankings by Mechanism# GLP-1 Monoagonists# GLP-1/GIP Dual Agonists# GLP-1/Glucagon Dual Agonists# GLP-1/Amylin Combinations# Triple Agonists# Antibody Conjugates# Weight Loss Per Week Comparison# Since trial durations vary widely, examining the rate of weight loss provides additional context: Note: This metric favors shorter trials because weight loss rate typically declines over time as patients approach a new steady state
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