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Qualifying Comorbidities FDA labeling and clinical guidelines commonly recognize: Hypertension (blood pressure ≥130/80 or taking antihypertensive medication) Type 2 diabetes (HbA1c ≥6.5% or on glucose-lowering medication) Prediabetes (HbA1c 5.7-6.4% or impaired fasting glucose) Dyslipidemia (elevated LDL, low HDL, or elevated triglycerides) Obstructive sleep apnea (diagnosed via sleep study) Cardiovascular disease (prior MI, stroke, coronary artery disease) Non-alcoholic fatty liver disease / MASLD Polycystic ovary syndrome (PCOS) with metabolic features Osteoarthritis weight-bearing joints Insurance formularies may be stricter — some require objective documentation (lab values, sleep study reports) rather than self-report

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Back when I was frequently recommending them, not much was known about their long-term side effects